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While a large number of clinical trials have been completed
2019-06-25
While a large number of clinical trials have been completed or underway, there is a lack of strong evidence of their effectiveness and safety. Some experts pointed out that autologous transplantation may put patients at a risk of receiving the genetically defective immune cells, while allogeneic tra
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Introduction Several types of cancers
2019-06-25
Introduction Several types of cancers, including those originating in the breast, prostate, and lung, have a propensity to metastasize to the bones [1,2]. Bone metastases severely impair skeletal metabolism, and result in important clinical sequelae, such as excruciating chronic bone pain and the s
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br Future perspectives Identification of LOX as a modulator
2019-06-25
Future perspectives Identification of LOX as a modulator of the ECM to form pre-metastatic niches and subsequently bone metastasis arose as we were investigating the hypoxia tumour secretome using existing patient cohort data and cutting edge proteomics. Although condoned by some researchers as “
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Uno de los rasgos m s in http
2019-06-25
Uno de los rasgos más interesantes que encontramos en este retrato (figura 1) es la madurez y prolijidad que Portinari Q-VD(OMe)-OPh structure en unos cabellos bien peinados —aunque con unas entradas muy pronunciadas y unas patillas perfectamente recortadas— en la piel marcada por el paso del tiemp
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br Una de las m
2019-06-25
Una de las más acres y reiteradas recriminaciones Peramivir la tl provenientes de los sectores eclesiales más conservadores, ha estado fundada en el uso del instrumental teórico de origen marxista y su tesis de la lucha de clases, debido a que se le atribuye una irreconciliable incompatibilidad co
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Accordingly blockade of TL A
2019-06-25
Accordingly, blockade of TL1A/Fas-L/TLR4 cascades and inhibition of the M1/Th1 differentiation associated with DcR3 might potentially rescue hepatic IR injury. However, the contribution of TL1A/Fas-L/TLR4 on the M1/M2 and Th1/Th2 balances, as well as pathogenic liver IR injury had never previously b
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br Materials and methods br Results br
2019-06-25
Materials and methods Results Discussion In recent years, it has been revealed that miRNAs are critical members of complex regulatory systems. SNPs or mutations occurring in the miRNA gene region may disturb the properties of miRNAs and result in defect in protein translation of target mRNA
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A year old male with known dextrocardia
2019-06-25
A 52-year-old male with known dextrocardia and CCTGA presented with a 2-month history of recurrent presyncope and effort intolerance. His examination revealed a resting pulse rate of 52beats/min (bpm) and a blood pressure of 130/80mmHg. The apex beat and heart sounds were appreciated on the right si
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customer reviews We report a case of DCML deficiency and MDS
2019-06-24
We report a case of DCML deficiency and MDS in a patient with GATA2 mutation who successfully underwent allogeneic stem cell transplantation. Case report At presentation, she had adapted to a hemoglobin level of 79g/l and had only occasional discrete symptoms of her anemia, as fatigue, other con
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br With respect to the
2019-06-24
With respect to the welfare of children and mothers, the transition from the Millennium Development Goals (MDGs) to Sustainable Development Goals (SDGs) is sometimes perceived as risky. The relevant MDGs had a focus on interventions to address maternal and child health, while the focus of the SDGs
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br Discussion In our patient series
2019-06-24
Discussion In our patient series, coronary angiography was performed routinely prior to electrophysiological study, revealing a 9.1% (5/55) incidence of significant coronary artery stenosis in patients with Brugada syndrome/Brugada-type ECG. Although acute myocardial ischemia has been reported to
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Our group then carried out a study to
2019-06-24
Our group then carried out a study to determine the substrate sites and arrhythmogenic mechanisms of the BrS [29]. We found that all our BrS patients had abnormal low voltage, fractionated late potentials exclusively clustering in the anterior aspect of the RVOT epicardium and not seen anywhere else
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GP ablation has been regarded as a vagal
2019-06-24
GP ablation has been regarded as a vagal denervation procedure that reduces the vagal tone in the atria and the vulnerability to AF. However, it is unclear how much vagal effect on the atrium is attenuated and how much of the atrium is denervated after the ablation. According to the GP mapping by Mc
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Reviewing the literature we knew that
2019-06-24
Reviewing the literature, we knew that in cases of AA, use of IST should be cautious, as IST might accelerate occult lymphoma escaping immune surveillance and evolving as a refractory lymphoma. Second, in cases of AA and concomitant NHL, to choose cytotoxic chemotherapy or IST is an art. Depending o
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The data also revealed notable differences in practice
2019-06-24
The data also revealed notable differences in practice patterns across the countries. In France, Italy, Spain and the UK, patients were most likely to have multiple disseminated sites of metastases at the time of initial bone Tranilast structure detection; however, patients in Germany were most lik
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