• AMP activated protein kinase AMPK

  2024-06-06

  

  AMP-activated protein kinase (AMPK) is a key cellular energy sensor that maintains energy homeostasis at the cellular and whole-organism level (Hardie et al., 2012). Functionally, the AMPK pathway sustains adenosine triphosphate (ATP) production through activation of fatty CGP 35348 oxidation and au

• br Conclusion We have identified three non competitive

  2024-06-06

  

  Conclusion We have identified three non-competitive inhibitors of the human and porcine APN with Ki values in the μM range, by combining virtual screening and kinetic assays. Molecular docking simulations suggest these novel inhibitors block APN activity by an alternative mechanism to Zn coordina

• br Results br Discussion By using

  2024-06-06

  

  Results Discussion By using an unbiased proteomic screen for xCT binding partners, followed by functional validation, we have made the surprising discovery that mTORC2 regulates amino Apamin metabolism in tumor cells by phosphorylating serine 26 of the cystine-glutamate antiporter xCT on its

• br Materials and methods br Results br Discussion br Conclus

  2024-06-06

  

  Materials and methods Results Discussion Conclusions These studies provide important mechanistic insights to explain the long-established physiological observation that obese adipose tissue has higher rates of basal lipolysis. Increased lipolysis contributes to increased hepatic Calpain

• Sphingolipids such as ceramides and glucosylceramides are

  2024-06-06

  

  Sphingolipids, such as ceramides and glucosylceramides, are an important class of bioactive lipids. The levels of these lipids change as a function of adipose tissue mass and functionality, and are partially driven by cellular availability of palmitoyl-CoA. Aberrant accumulation of ceramide, glucosy

• There has been growing interest over computational methods t

  2024-06-06

  

  There has been growing interest over computational methods to predict the biological activity by chemical structure, so as to decide whether it AN-2728 has objective qualities or not. In this contribution, the well-known method, which is called quantitative structure–activity relationship (QSAR) [1

• We have expressed the ECDs of the

  2024-06-06

  

  We have expressed the ECDs of the human α1, β1, γ and ɛ AChR subunits in the past using the methylotropic yeast Pichia pastoris as soluble glycosylated proteins [15], [16]. Further work with the γ subunit ECD revealed a marked improvement of the solubility and yield following the mutation of hydroph

• With the treatment options available today including a

  2024-06-06

  

  With the treatment options available today including a combination of symptomatic treatments and general immunosuppression, many MG patients can lead productive lives [1], [4], [20]. The frequency of death has decreased due to improved management and detection of milder cases. At present, the overal

• In vitro studies with soman inhibited non aged

  2024-06-06

  

  In vitro studies with soman-inhibited, non-aged AChE revealed a species dependent reactivating potency of HI-6 and MMB-4. With guinea pig AChE second order reactivation rate constants of 0.051 and 0.038mM−1min−1 were determined for HI-6 and MMB-4, respectively (Luo et al., 2007). Corresponding valu

• br Conclusion br Conflicts of interest br Introduction RNA

  2024-06-06

  

  Conclusion Conflicts of interest Introduction RNA interference is a specific post-transcriptional gene silencing mechanism within a cell via the transfection of microRNAs (miRNA), exogenous small interfering RNAs (siRNA) or small hairpin RNAs (shRNA) [1–3]. Transfection of shRNA can be done

• Prostate cancer is the second leading cause of cancer

  2024-06-06

  

  Prostate cancer is the second leading cause of cancer-related death in men in the United States [25]. Similar to pancreatic cancer, prostate cancer has few diagnostic options available, particularly to differentiate indolent from aggressive disease. Axl is also overexpressed in ∼50% of prostate canc

• br Role of autophagy in alcoholic cardiomyopathy br

  2024-06-06

  

  Role of autophagy in alcoholic cardiomyopathy Concluding remarks The genetic and phenotypic heterogeneity in alcoholic cardiac injury has been recognized despite the seemingly beneficial effects of low to moderate alcohol consumption [8]. Although oxidative stress is well established in the pa

• If the lack of specificity and the

  2024-06-06

  

  If the lack of specificity and the high pleiotropy may represent a problem in view of the potential chemotherapeutic features of autophagy-inducing agents, it PF 1022A may switch into an advantage in the case of chemopreventive strategies. In fact, as non-pharmacologic interventions such as limited

• We subsequently performed immunohistochemistry on sections o

  2024-06-05

  

  We subsequently performed immunohistochemistry on sections obtained from mice at 16 weeks after surgery. Type II collagen expression was detected in all articular cartilage zones, but was weak in the upper zone in the vehicle-treated group. MMP-13 and type X collagen expression were increased in the

• Several combination studies have been performed using animal

  2024-06-05

  

  Several combination studies have been performed using animal models of mucormycosis, principally involving R. arrhizus. In two investigations using diabetic and/or neutropenic mice, a combination of a polyene with an echinocandin was shown to improve survival compared with monotherapies [25], [34].

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