• Besides being an energy storing tissue adipose tissue acts a

  2020-02-25

  

  Besides being an energy storing tissue, adipose tissue acts as an active endocrine organ that secretes a number of biologically active adipokines involved in multiple physiological processes such as inflammation and lipid and glucose metabolism, with direct and indirect effects on reproduction [15,1

• Introduction The carnitine choline acyltransferase family is

  2020-02-25

  

  Introduction The carnitine/choline acyltransferase family is a family of enzymes that play diverse roles, ranging from (the regulation of) arginase inhibitor mg and fuel metabolism in mitochondria and peroxisomes to the generation of the neurotransmitter acetylcholine. In mammals, this family consi

• The contradictory effects exerted by metals

  2020-02-25

  

  The contradictory effects exerted by metals were reviewed by Nunes (2011) that stated that the concentration and the species of metal can cause specific effects in ChE activity. Being environmentally exposed, the organism can accumulate metals in tissues, increasing their concentrations. Some author

• In the literature we can find two different modes of

  2020-02-25

  

  In the literature, we can find two different modes of action for estrogens: Firstly there is the commonly accepted genomic pathway. Estrogens pass the cell membrane due to their lipophilic character via diffusion and bind to estrogen receptors (ERs) in the cytoplasm. After binding a dimerization of

• The third challenge is to understand the mechanisms of

  2020-02-25

  

  The third challenge is to understand the mechanisms of drug resistance. There are several different mechanisms of ES tumor to develop drug resistance. First, cancer stem cells are capable of proliferate and generate tumor cells with new sets of mutations which may harbor different protein targets [1

• br Conclusion br Acknowledgments This work was supported by

  2020-02-25

  

  Conclusion Acknowledgments This work was supported by Progetto PON - “Ricerca e Competitività 2007–2013” - PON01_01802: “Sviluppo di molecole capaci di modulare vie metaboliche intracellulari redox-sensibili per la prevenzione e la cura di patologie infettive, tumorali, neurodegenerative e lor

• Our finding that activating DDR

  2020-02-25

  

  Our finding that activating DDR2 variants are a cause of this disease suggested that the ABL inhibitor dasatinib, a leukemia drug that also inhibits DDR2, could be used for treatment of affected individuals.10, 11 To examine the effect of dasatinib on p.Leu610Pro- and p.Tyr740Cys-induced autophospho

• casein kinase Previous studies in the Swiss

  2020-02-25

  

  Previous studies in the Swiss Webster mouse (Rosengren et al., 1995) and the Sprague–Dawley rat (El Sisi et al., 1993) have shown that retinol pretreatment potentiates the hepatotoxicity of paracetamol. The current study is designed to investigate further this interaction in mice. To accomplish this

• In the present study BACH

  2020-02-25

  

  In the present study, BACH1 downregulation did not correlate with nuclear accumulation of NRF2, suggesting that these changes were triggered via an independent mechanism. BACH1 is a transcriptional repressor that is regulated by heme. Heme binding to the BACH1 C-terminal domain inhibits BACH1 DNA bi

• A major finding to emerge from this study

  2020-02-25

  

  A major finding to emerge from this study is a conserved regulatory scheme deployed by both innate and adaptive lymphocytes, which is coordinated by a cohort of TFs. The scheme functionally compartmentalizes effector c di gmp that circulate between blood and peripheral tissues from self-renewing pr

• A study profiling chemokine expression in LCLs revealed

  2020-02-25

  

  A study profiling chemokine expression in LCLs revealed high expression levels of CCR6, CCR7, and CCR10 and low expression of CXCR4 and CXCR5 in EBV immortalized cells. Accordingly, LCLs showed a markedly increase in migration in response to the ligands of CCR6 (CCL20), CC7 (CCL21), and CCR10 (CCL28

• Several eukaryotic E enzymes including BRE RNF and RAD have

  2020-02-25

  

  Several eukaryotic E3 enzymes, including BRE1 [49], RNF8 [50], and RAD18 [24], [51], have been reported to partner with UBE2B in the ubiquitination of various targets. We examined the expression levels of these E3 enzymes in HONE1 and TW01 cells; RAD18 was highly expressed in these Dinaciclib (data

• br A brief introduction to DUBs The reversal of ubiquitin

  2020-02-25

  

  A brief introduction to DUBs The reversal of ubiquitin conjugation of targeted proteins relies on deubiquitinating bafilomycin a1 autophagy (DUBs), which catalytically cleave single Ub or poly-ubiquitin chains from proteins. The human genome encodes approximately 100 potential DUBs which can be

• Based on the similar activities of

  2020-02-24

  

  Based on the similar activities of Rad6p and Cdc34p (i.e., both are E2 ub-conjugating enzymes) on ubiquitinylation of p33 replication protein, we propose that Rad6p and the plant Ubc2p mono- and bi-ubiquitinate the viral replication proteins in order to facilitate the recruitment of the cellular ESC

• In conclusion we have found that

  2020-02-24

  

  In conclusion, we have found that Egr1 can play an inhibitory role on DBH promoter-driven transcription. This inhibition requires a newly identified Egr1 response SB 239063 at the −227/−224 region of DBH promoter. This inhibition appears to result from Egr1 directly bound to the DBH promoter. We sp

14648 records 805/977 page Previous Next First page 上5页 801802803804805 下5页 Last page