• br User knowledge representation Various representation appr

  2021-04-21

  

  User knowledge representation Various representation approaches of user interests and preferences are proposed. In this work, we advocate a multidimensional semantic approach based on Bouzghoub et al. meta-model (Bouzeghoub and Kostadinov, 2005), depicted in Fig. 6, to model the user profile. The

• The first mammalian mutation linked to CR was

  2021-04-21

  

  The first mammalian mutation linked to CR was identified in golden hamsters (Mesocricetus auratus). The mutation was an autosomal allele first described in the late 1980s [8] and was identified using positional cloning [9]. These animals displayed a shortened period length (20h in homozygous animals

• Besides having a remarkable progestogenic effect

  2021-04-21

  

  Besides having a remarkable progestogenic effect, an additional characteristic of DRSP is its strong antimineralocorticoid effect and antiandrogenic action [11]. DRSP is characterized by an antimineralocorticoid effect that is stronger when compared to progesterone. The decreasing synthesis of proge

• Another interesting finding regarding substrate selectivity

  2021-04-20

  

  Another interesting finding regarding substrate selectivity of iPLA2-VIA in whole cellular systems stems from the observation that some of the major species hydrolyzed by the enzyme contain a 16:1 fatty extra at the sn-2 position [57,119], raising the possibility that iPLA2-VIA may constitute a maj

• Why are Tfh cell dynamics so fundamentally different

  2021-04-20

  

  Why are Tfh cell dynamics so fundamentally different in naive and immune animals? Initially, GC BS-181 must pass stringent affinity and specificity checkpoints to ensure only high-affinity non-self-reactive cells are selected. Therefore, restricting primary Tfh cells with the greatest helper capaci

• br Conclusions br Conflict of interest

  2021-04-20

  

  Conclusions Conflict of interest statement Acknowledgments This research was funded by São Paulo Research Foundation (FAPESP) (ProcessN. 2012/08621-1). Thanks to F.J.H. Blázquez and the staff of the Laboratório de Anatomia Microscópica e Imuno Histoquímica (LAMIH − FMVZ − USP) for the permi

• K02288 br Materials and methods br Results br Discussion

  2021-04-20

  

  Materials and methods Results Discussion Although autophagy is known to be implicated in the therapeutic effect of DNA alkylating agents such as MNNG [28], [29], [30], the molecular mechanisms underlying autophagy induced by MNNG remain largely elusive. In this study, we present evidence sh

• Annexin V-Cy3 Apoptosis Kit Plus Previous studies from our l

  2021-04-20

  

  Previous studies from our lab looked at the effect of interfering with crossover helix interactions in TS-DHFR. One study utilized peptide mimetics of the crossover helix to inhibit wild-type TS-DHFR noncompetitively, and with an IC of 230 μM. A second study used a virtual screening approach to iden

• Dehydrogenation by a KSTD is also

  2021-04-20

  

  — 1(2)-Dehydrogenation by a Δ1-KSTD is also a crucial step during Glucose Uptake Fluorometric Assay Kit australia degradation of the steroid core. Several Δ1-KSTDs were shown to be active under either aerobic or anaerobic conditions [27,29,47,50,66]. Furthermore, the last common intermediate of bot

• For radiochemotherapy it is well known

  2021-04-20

  

  For radiochemotherapy, it is well known that mitotic cell death and apoptosis present the major cell death modes. More recently, autophagy-dependent cell death has been described to occur upon radiochemotherapy (Daido et al., 2005, Song et al., 2017). This form of regulated cell death depends on com

• Dabigatran br Introduction Noncanonical nucleoside triphosph

  2021-04-20

  

  Introduction Noncanonical nucleoside triphosphates (NTPs; such as deoxyinosine triphosphate (dITP), deoxyxanthosine triphosphate (dXTP), 8-oxo-deoxyguanosine triphosphate, and 2-oxo-deoxyadenosine triphosphate are produced from oxidation, deamination, or other modifications of canonical nucleotid

• br Material and methods br

  2021-04-19

  

  Material and methods Results Diagrammatic representations showing the bilateral injection sites in the BNST of all animals used in the present study are presented in Fig. 1. Discussion The present results provide the first evidence that both CRF1 and CRF2 receptors in the BSNT are involved

• In silico modelling studies might aid our understanding of

  2021-04-19

  

  In silico modelling studies might aid our understanding of the functionality and potential biological activity of food and, in the long-term they might underpin the development of personalised diets to reduce health risks and help us to better understand pharmaceutical/food interactions. Acknowle

• The intimate interactions between flavonoids and

  2021-04-19

  

  The intimate interactions between flavonoids and ERα have been more extensively studied than their ERβ interactions because of the dominant role of ERα in some important diseases (Ye et al., 2018) including breast cancer (more than 80% of human breast cancers are ERα positive) (Turner et al., 2015),

• In conclusion our findings suggested that

  2021-04-19

  

  In conclusion, our findings suggested that EP4 receptor activation triggers apoptosis in B-cell lymphoblasts. Our results also showed that EP4 receptor engagement inactivates NF-κB, which, in turn, sensitizes Ramos BAY 80-6946 synthesis to apoptosis induced by chemotherapeutic agents. EP4 receptor

15341 records 644/1023 page Previous Next First page 上5页 641642643644645 下5页 Last page