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br Experimental procedures br Introduction Protein kinases r
2020-02-24
Experimental procedures Introduction Protein kinases represent one of the largest enzyme Imiquimod hydrochloride in the human genome and act as signaling mediators in a variety of cellular processes (Manning et al., 2002). Because many diseases are associated with aberrant protein kinase acti
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Preparation of the pyridyl ether analogs
2020-02-24
Preparation of the 2-pyridyl ether analogs (–) was accomplished by alkylation of alcohol with 2-bromopyridines in the presence of NaH to afford the desired pyridyl ether analogs in low to moderate yield. Preparation of the 3-pyridyl analog was carried out by conversion of alcohol to the tosylate, fo
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Depending on the needs of the
2020-02-24
Depending on the needs of the product to be preserved, there are several levels of barrier packaging. Usually they are classified into low and high barriers. High barriers have a low oxygen transmittal rate, low moisture vapor transmission rate, and a high tensile strength, or puncture resistance. W
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ASP015K As compared with the broad spectrum of
2020-02-22
As compared with the broad spectrum of chemicals known to serve as the ligands for PXR and CAR, the ligands of VDR are previously restricted to VD3 as well as its hydroxylated metabolites and the secondary bile ASP015K LCA. Recently, the VDR-binding capacities of more compounds have been discovered,
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The CRTH inhibitory activities of the synthesized
2020-02-22
The CRTH2 inhibitory activities of the synthesized compounds are listed in , . At first we introduced halogen or other substituents at the 4,4′-position of phenyl rings in the benzhydryl moiety in order to obtain SAR and to improve the metabolic stability at this moiety (–). It is well-known that in
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11-dUTP The most important cytotoxic lesion formed by the
2020-02-22
The most important cytotoxic lesion formed by the nitrogen mustards is generally considered to be the DNA–DNA interstrand cross-link 12, 13. DNA–DNA interstrand cross-links are thought to exert their cytotoxic effects by inhibiting DNA duplex strand separation, progression of the 11-dUTP fork and DN
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Piperaquine The enzyme cyclooxygenase COX or prostaglandin e
2020-02-22
The enzyme cyclooxygenase (COX) or prostaglandin endoperoxide H synthase (PGHS) is the key enzyme in the conversion of arachidonic Piperaquine (AA) into prostaglandins (PGs) [1]. In 1991, researchers found that there were two isoforms of this enzyme called COX-1 and COX-2 with independent genes and
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Gardiquimod Amphiphilic compounds lower interfacial tension
2020-02-22
Amphiphilic compounds lower interfacial tension and its biological production often results in a competitive environmental advantage (Darvishi et al., 2011). The reduction of interfacial tension can increase the biologically available surface areas resulting in increased metabolism of insoluble comp
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Only a few studies have examined
2020-02-22
Only a few studies have examined the effect of prostanoids on cardiac fibroblasts. Therefore, this study examines the effect of PGE2 on cardiac fibroblast proliferation and tests the hypothesis that PGE2 causes cardiac fibroblast proliferation via alterations of PEG Virus Precipitation Kit regulato
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br Protein protein interactions of LEI L DNase
2020-02-22
Protein-protein interactions of LEI/L-DNase II and the control of cell death Evolutionary tips The serpin inhibitory mechanism is extremely well adapted to evolutionary changes because a single amino (+)- Corydaline substitution in the RSL can led to the inhibition of a totally different prot
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Although PQQ has nutritional importance and
2020-02-22
Although PQQ has nutritional importance and pharmacological effects in higher organisms, including humans [15], until recently, there was no clear evidence for the use of PQQ as a co-factor in a eukaryotic enzyme. This review presents a novel eukaryotic PQQ-dependent quinohemoprotein recently discov
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Cytochrome P CYP enzymes plays an essential role in
2020-02-22
Cytochrome P450 (CYP-450) enzymes plays an essential role in pharmacology of drugs and toxicology of xenobiotics. Inhibition of these enzymes may lead to increase plasma levels of a concomitantly administered drug (Lee et al., 2013). It may prolong or reduce the pharmacological effects and increase
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br Transparency document br Acknowledgments This
2020-02-22
Transparency document Acknowledgments This work was supported by the Ministry of Education, Youth and Sports of the Czech Republic (the National Program of Sustainability I, Grants LO1204 and LO1304), by the Czech Science Foundation (15-17282Y) and by Palacký University Olomouc (IGA_PrF_2017_0
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Magnified regions of the upregulated proteins identified by
2020-02-22
Magnified regions of the upregulated proteins identified by MALDI-TOF are shown in Fig. 2. The identified proteins were phosphoglycerate kinase, fructose-bisphosphate aldolase class II, alcohol dehydrogenase, phosphoglyceromutase, 6-phosphogluconolactonase, malate dehydrogenase, alkyl hydroperoxide
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Importantly our in vivo data fit to the in
2020-02-22
Importantly, our in vivo data fit to the in vitro data, further confirming the synergistic effect of XJD and gefitinib on the inhibition of lung cancer and the regulation of SP1, HOTAIR, and EP4 MLN120B levels. The doses of XJD used were based on our previous in vivo study (Zhao et al., 2016). We be
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