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br Materials and methods br Results The i v administration
2020-05-05
Materials and methods Results The i.v. administration of urocortin 2 reduced the mean arterial blood pressure in a dose-dependent manner (Fig. 1). The ED50 for the urocortin 2 cumulative dose–response effect on mean arterial blood pressure was 0.014±0.004 mg kg−1. Urocortin 2 administration ha
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Another novel finding of our study
2020-05-05
Another novel finding of our study was that the global 5 hmC was down-regulated and was associated with a substantial reduction of TET expression in the PE placentas compared with the controls. The decreased global 5 hmC level was consistent with the increased global 5 mC level in the preeclamptic p
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The role of ARA cyp metabolites in the liver is
2020-04-30
The role of ARA-cyp450 metabolites in the liver is still unclear [44]. However, ARA-cyp450 genes metabolize other fatty acids such lauric and palmitic Epalrestat receptor [45]. It was found that decreased cyp4a expression caused fatty livers through reduction of fatty acid metabolism [46]. In this
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Neuropsychological studies of adults with problem gambling i
2020-04-30
Neuropsychological studies of adults with problem gambling indicate impairments in many cognitive areas including inhibition, working memory, decision-making, cognitive flexibility, and executive planning (Ledgerwood et al., 2012, Goudriaan et al., 2006). Dopamine is a neurotransmitter that regulate
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Furthermore the determination of downstream target genes ind
2020-04-30
Furthermore, the determination of downstream target genes induced by CdCl2 is noteworthy and can help to define its underlying carcinogenesis mechanism. Therefore, we evaluated c-fos and c-jun expression which are stimulated by estrogen through ERK/MAPK pathway. These are not only proto-oncogenes wh
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Our results indirectly support the combination of resveratro
2020-04-30
Our results indirectly support the combination of resveratrol and hesperatin treatment for PDN, as this induces GLO1 activity in patients (Xue et al., 2016), as well as metformin, an FDA-approved anti-diabetic treatment, which acts as an MG scavenger to reduce MG levels in type 2 diabetic patients (
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High concentrations of kC may also
2020-04-30
High concentrations of 7kC may also arise from dietary intake of processed cholesterol-rich food, likely favoring or worsening inflammatory bowel disease (IBD) [5,13]. Furthermore, IBD has been associated with a dysregulation of colonic 11β-HSD expression, exhibiting increased 11β-HSD1 and decreased
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An important role for the precursor
2020-04-30
An important role for the precursor molecule of the main EBI2 ligand, 25-OHC, in the inhibition of inflammation was recently shown. 25-OHC was demonstrated to inhibit inflammasome induction in mouse macrophages [28]. Inflammasome assemblies are the sites of caspase 1 activation and lead to the gener
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br Patients and Methods Patients who
2020-04-30
Patients and Methods Patients who had been initiated on a DPP-4 inhibitor (see in the online version at doi:10.1016/j.clinthera.2018.06.002) between April 2012 and June 2017, when the common threshold for dose adjustment for all non-linagliptin DPP-4 inhibitors was a creatinine clearance (CrCl)
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br Conclusion The role of DNA PK target in DNA
2020-04-30
Conclusion The role of DNA-PK target in DNA DSB repair renders this UNC2881 kinase of great medicinal interest in cancer chemotherapy especially the cancer types of linked to DNA defects. Due to the absence of 3D DNA-PK target structure, different ligand-based methods were applied for design of
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The data from drug screening in P berghei Fig D
2020-04-30
The data from drug screening in P. berghei (Fig. 3D) provide proof of concept that chemogenomic profiling can be accomplished in P. berghei in the same manner as P. falciparum, in that significant increases in the EC50 ratio were found only for antifolate drugs in the parasite with attenuated TgDHFR
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Trk receptors critically support the development and mainten
2020-04-29
Trk receptors critically support the development and maintenance of the nervous system, , but their over-expression in various neural and non-neural neoplasms such as breast, pancreatic, lung and neuroendocrine tumors also confers aggressive phenotypes to tumor Schaftoside and correlates with poor p
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To evaluate the new quadrupolar CPA qCPA the pure
2020-04-29
To evaluate the new quadrupolar CPA (qCPA) the pure fluid properties of CO2 are predicted both in the critical region and in the compressed liquid region. The model is furthermore applied for the prediction and correlation of binary mixtures with CO2 and n-alkanes, water, alcohols and a few quadrupo
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Natural progestogens play an important
2020-04-29
Natural progestogens play an important role in the stimulation of oocyte growth and maturation as well as in spermatogenesis and sperm maturation, and they act as sex pheromones in teleost fish (Kime, 1990, Kobayashi et al., 2002, Nagahama and Yamashita, 2008, Scott et al., 2010). A complex series o
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br Methods br Results br Discussion The findings of this
2020-04-29
Methods Results Discussion The findings of this study indicate that an ET system including ET-1 and ET-2 as well as ET receptors are present in the retina and RPE/choroid, and are up-regulated by both hypertension and diabetes. Specifically, individual antagonism of the ETRA or ETRB deliver
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