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br STAR Methods br Acknowledgments We
2020-06-19
STAR★Methods Acknowledgments We would like to thank Dr. Tsung-Ping and Dr. Shang-Yi Tsai, National Institute on Drug Abuse, NIH for sharing protocols on pulse chase experiments and analysis. We would like to thank Dr. William G. Telford for his valuable input on Amnis flow cytometry experiment
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PTEN is an evolutionarily conserved protein and
2020-06-19
PTEN is an evolutionarily conserved protein and has been considered to be genetically unique without other isoforms. In this study, we identified an alternate translation initiation at a CUG site in the 5′ untranslated region (5′ UTR) of PTEN mRNA. This CUG start alverine generates a larger form of
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The identification of CCR B
2020-06-19
The identification of CCR6+ bromfenac within the LZ as direct progenitors of MBCs provides a new window into the evolution of immune responses. In practical terms, flow-cytometric detection of CCR6+ GC B cells could provide a means of rapidly assessing vaccine efficacy when applied to fine needle a
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br Results and Discussion br Conclusions
2020-06-19
Results and Discussion Conclusions Understanding the connections between function and fitness is a primary goal of many biological disciplines including systems biology and molecular evolution. While sound approaches have been developed to understand the connections between function and fitnes
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br Materials and methods br Results br
2020-06-19
Materials and methods Results Discussion In this study, we uncovered a female-specific haplotype-MDD vulnerability association, by which a two-marker haplotype TG of rs4633-rs4680 may link to enhanced MDD risk in females. Female haplotype TG carriers were estimated to have a 9.17-fold incre
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RCT pathway plays a critical role in the maintenance
2020-06-19
RCT pathway plays a critical role in the maintenance of cholesterol homeostasis by facilitating the cholesterol clearance and cholesterol efflux (Levinson & Wagner, 2015). In the process of RCT, ABCA1 and ABCG1 played as crucial regulators in cholesterol efflux (Yasuda et al., 2011). Compared with h
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ERR is expressed in several adult and embryonic
2020-06-19
ERRγ is expressed in several adult and embryonic tissues but its biological role is still largely unknown [21]. Overexpression of ERRγ in breast cancer correlates with a favorable outcome [22]. In addition, ERRγ has been reported to inhibit the growth of prostate tumor Flavin adenine dinucleotide [2
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Tarafenacin sale Then the mechanisms responsible for BPA
2020-06-19
Then the mechanisms responsible for BPA induced up regulation of ERRγ were further investigated. Recent studies indicated that Akt and MPAK can modulate the protein levels and transcriptional activities of ERRγ (Heckler et al., 2014, Sun et al., 2014). Previous studies also indicated that BPA can ac
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The T cell receptor TCR pathway is associated with T
2020-06-19
The T cell receptor (TCR) pathway is associated with T cell activation and differentiation. When specific antigen peptides are recognized by the TCR, lymphocyte-specific protein tyrosine kinase (lck) phosphorylates the immune-receptor tyrosine-based activation motifs (ITAMs) of the TCR-CD3 complex a
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br Material and methods br Results and discussion br
2020-06-19
Material and methods Results and discussion Conclusions Prostanoid-E receptor selective antagonists that inhibit EP2 or EP4 receptor activities may be used as a pharmacological strategy to limit cyst formation and ADPKD progression. Our study follows on from our previous observations of the
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br Fragment based drug discovery FBDD is a
2020-06-18
Fragment-based drug discovery (FBDD) is a powerful method to discover drug leads and has been widely adopted in both academia and industry. FBDD can be used to explore chemical 2076 space with libraries which are smaller in size, producing drug leads with high ligand-binding efficiency. It also p
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After repeated intermittent exposure to a psychostimulant an
2020-06-18
After repeated, intermittent exposure to a psychostimulant an augmentation of drug response to motor activity is commonly observed, a phenomenon known as behavioral sensitization (Kalivas and Stewart, 1991, Steketee and Kalivas, 2011). On the other hand, several reports have pointed out that stress
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Studies of LRRK tagged with green
2020-06-18
Studies of LRRK2 tagged with green fluorescent protein revealed the presence of monomeric LRRK2 in the Gemcitabine of living cells, while LRRK2 oligomers were found in the proximity of the plasma membrane, suggesting that both oligomerization status and compartmentalization of LRRK2 defines its fun
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r407 br Acknowledgement This study was supported by Vetenska
2020-06-18
Acknowledgement This study was supported by Vetenskapsrådet, Sweden (Grant 2017-02918). Introduction Soybean is a major source of protein and oil used for food and feed, as well as for the production of industrial products like lubricants and hydraulic fluids (Choudhary and Tran, 2011; Hsien,
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Many studies have documented that enolase acts as a plasmino
2020-06-18
Many studies have documented that enolase acts as a plasminogen-binding protein and this interaction is involved in the tissue invasion and pathogenicity of the causative agents (Almeida et al., 2004; Avilan et al., 2000; Marcilla et al., 2007; Mundodi et al., 2008; Vanegas et al., 2007). Furthermor
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