• br Peptide Antagonists The first endothelin receptor antagon

  2020-07-27

  

  Peptide Antagonists The first endothelin-receptor antagonists to be discovered were from natural product screening, Methyllycaconitine citrate libraries, or drug design based on the structure of the endogenous ET peptides (Table 1). The most widely used, according to the number of published arti

• The aim of this work is to explore different

  2020-07-27

  

  The aim of this work is to explore different recycling pde-5 inhibitors as fusion partner for two oxidoreductase enzymes (BVMO and ADH), and to compare their strengths and weaknesses for biocatalytic applications. We fused three different regenerating enzymes to a BVMO (TmCHMO, from Thermocrispum m

• The levels of circulating pro inflammatory cytokines are mar

  2020-07-27

  

  The levels of circulating pro-inflammatory cytokines are markedly elevated in ESRD, and have been speculated to play an important role as causative factors in a number of uremic complications [37]. The impairment of phagocyte functions and deregulated cytokine productions are highly prevalent in CRF

• In summary the loss of seven Cyp a

  2020-07-27

  

  In summary, the loss of seven Cyp3a genes lead to sexual dimorphic changes during the eight weeks of high fat diet treatment with Cyp3a-null female mice showing a healthier acclimation to a high fat diet through decreased weight gain, higher adiponectin, lower B-OHB levels, and a better response to

• [Ala107]-MBP (104-118) receptor Mounting evidences show that

  2020-07-27

  

  Mounting evidences show that the [Ala107]-MBP (104-118) receptor glutamate metabolism plays an essential role in the pathophysiology of epilepsy. Administrating glutamate to experimental animals can contribute to seizure onset [3], by contrast, the symptom of seizures alleviated by coadministration

• The BTBR are an inbred strain of mice which

  2020-07-27

  

  The BTBR are an inbred strain of mice, which display social deficits, reduced ultrasonic vocalizations in social settings, and high levels of repetitive self-grooming (Blanchard et al., 2012). Learning and memory deficits have been reported for BTBR in fear conditioning, water maze reversal, discri

• CXCL and CXCR have recently been described in cartilaginous

  2020-07-27

  

  CXCL16 and CXCR6 have recently been described in cartilaginous fish (Nomiyama et al., 2011, Venkatesh et al., 2014). In humans, the CXCR6 gene resides upstream of the FYCO1 gene in chromosome 3 and is clustered with several other inflammatory chemokine receptors including XCR1, CCR1–3, CCR5, CCR8 an

• For CRM substrate binding to occur

  2020-07-27

  

  For CRM1-substrate binding to occur, the cargo molecule must have a leucine-rich NES (Wen et al., 1995, Fukuda et al., 1997). The NES for CRM1 contains hydrophobic amino acids, including isoleucine, leucine, methionine, phenylalanine, and valine (Kutay & Guttinger, 2005). A consensus motif for this

• Nuclear export of the S

  2020-07-27

  

  Nuclear export of the 40S and 60S ribosomal subunits is dependent on CRM1 in eukaryotic cells, and mediated by the binding of the 60S ribosomal export protein NMD3 adaptor protein in RanGTP-dependent manner (Thomas & Kutay, 2003) (Fig. 1F). The CRM1-NMD3 complex has been detected in nucleoli, which

• To confirm and extend those

  2020-07-27

  

  To confirm and extend those findings of a differential interaction between hCrm1 and mCrm1 and Rev-RRE, we first attempted to use the yeast two and three hybrid systems, but failed to observe a detectable interaction between any of the Crm1s and Rev, in the presence or absence of HIV RRE RNA. We the

• There is evidence of R involvement in amphetamine effect

  2020-07-27

  

  There is evidence of σ2R involvement in amphetamine effect on dopamine transport (Izenwasser et al., 1998; Weatherspoon and Werling, 1999). In addition, treatment with σ2R antagonists counteracts cocaine-induced locomotor stimulation in mice (Guo and Zhen, 2015; Lever et al., 2014). Our results now

• In the current study although EP agonist was the

  2020-07-27

  

  In the current study, although EP4 agonist was the most effective in relaxing corpus cavernosum, it Iodoacetyl-LC-Biotin mg did not affect the neuronally-mediated relaxation. On the other hand, both alprostadil and iloprost, which were less effective as direct relaxants, potentiated EFS-induced rel

• One contribution to knowledge of that research is

  2020-07-27

  

  One contribution to knowledge of that research is the POE Safety Pattern (PSP; [25]), shown on the right of Fig. 6, a process pattern for capturing high-level descriptions of system requirements and domain properties and assumptions through detailed problem models coupled with their traceable and ju

• br Materials and methods br Results

  2020-07-25

  

  Materials and methods Results Discussion EP is an important tick borne disease caused by T. equi and B. caballi. Current chemotherapeutic drugs for EP are limited, as only diminazene aceturate and imidazole dipropionate are available. Novel and effective chemotherapeutics for treatment of E

• Enolases are among the most abundantly expressed

  2020-07-25

  

  Enolases are among the most abundantly expressed cytosolic proteins. They are metalloenzymes that catalyze the conversion of 2-phosphoglycerate to phosphoenolpyruvate [18]. Eubacteria and archaebacteria have a single enolase gene (reviewed in [19]). Despite the lack of signal peptides or cognate pro

14168 records 697/945 page Previous Next First page 上5页 696697698699700 下5页 Last page