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A strong support for a dual role
2020-07-31
A strong support for a dual role of microglia may be due to distinct microglial phenotypes, which have been broadly categorized into classical pro-inflammatory M1 phenotype and alternative anti-inflammatory M2 phenotype [70,71]. In consistent with these findings, we observed that MPA significantly
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It was found that inhibiting
2020-07-31
It was found that inhibiting TdT in some cancer cells can kill them, such as in acute lymphoblastic leukemia cells [86]. Chemical compounds were designed and synthesized using TdT as a drug target [87, 88] and the structure of some of these compounds was solved in their bound form []. The length of
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DHFR deficient Chinese hamster ovary CHO DHFR cells
2020-07-31
DHFR-deficient Chinese hamster ovary (CHO DHFR−) xmu are one of the most popular mammalian expression system for inducible amplification of transgene. Target gene is generally subcloned into vectors containing the dihydrofolate reductase (DHFR) gene which serves as the selective marker gene in CHO
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We have reported previously that aminoacrylate derivatives o
2020-07-30
We have reported previously that β-aminoacrylate derivatives of the general structure () are inhibitors of DHODH. In particular, tricyclic derivatives and displayed sub-micromolar IC values against DHODH, and in the case of there was a 1000-fold greater potency compared to the human enzyme (DHOD
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The presence of H PPases in
2020-07-30
The presence of H+-PPases in parasitic protists raises the question of the physiological role of these proteins. So far, they had been extensively characterized mainly in higher plants, and some prokaryotes [1], [2], [3], [4], [5], [6], [7], [16], [20]. A common feature to all these organisms is tha
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Determining the role of DAPK in animal
2020-07-30
Determining the role of DAPK in animal models of disease, such as the rat model of perinatal hypoxic-ischemic injury, can best be facilitated by the use of bioavailable small molecule inhibitors of DAPK. For example, a potential DAPK activity responsible for mediating initial cell death following HI
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This provides the rationale that covalent or
2020-07-30
This provides the rationale that covalent or non-covalent inhibitors of rhodesain may be advanced into the drug development pipeline against African sleeping sickness. To discover rhodesain inhibitors, we employed the irreversible tethering method to discover covalent inhibitors of cysteine protease
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Flow cytometric analyses indicated that CysLT receptor posit
2020-07-30
Flow cytometric analyses indicated that CysLT2 receptor-positive leukocytes included Siglec F+ Melphalan (eosinophils), CD11c+ F4/80+ cells (alveolar macrophages), and CD11c+ I-A/I-E+ cells (conventional dendritic cells). Only a small percentage of Gr-1+ cells (neutrophils) was positive for CysLT2
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The patulin in the apple juice was obtained
2020-07-30
The patulin in the apple juice was obtained from the rotten apple, which is contaminated by penicillium expansum. The known strategies for detoxification of patulin in apple juice include physical, biological and chemical methods. Propylthionl functionalized SBA-15 was found to reduce patulin levels
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The bicyclams are inhibitory to syncytium formation although
2020-07-30
The bicyclams are inhibitory to syncytium formation, although their IC50 in these assays are about 10–100 fold higher than their IC50 in the viral replication assays (De Clercq et al., 1994). This can also be explained by their interaction with fusin on the CD4+ target NS 1619 sale or on the persist
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Targeting of the colony stimulating
2020-07-30
Targeting of the colony stimulating factor-1 receptor (CSF-1R) has emerged as a strategy to ablate MDSCs or inhibit their tumor-promoting functions (Manthey et al., 2009; Patel and Player, 2009). CSF-1 is a cytokine frequently produced by several cancers, including melanoma, pancreatic cancer, and b
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br Results br Discussion Here we describe a specific and
2020-07-30
Results Discussion Here we describe a specific and potent CSF-1R targeting antibody, RG7155, that shows significant clinical activity in Dt-GCT patients and reduces TAMs in tumors of patients suffering from various cancers. In contrast to RG7155’s blocking both ligand-dependent and -independen
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oxoG is the most common oxidative DNA lesion
2020-07-29
8oxoG is the most common oxidative DNA lesion that has been studied in both eukaryotic and bacterial transcription systems. When located in the template DNA strand, it promotes misincorporation of jnk inhibitor and causes weak transcriptional pausing by both bacterial and eukaryotic RNAPs [[5], [6]
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Lestaurtinib receptor Our results signify that both membrane
2020-07-29
Our results signify that both membrane-anchored and soluble isoforms of DDR ECD Lestaurtinib receptor may be important in ECM remodeling. In this regard, several soluble collagen-binding proteins secreted in the ECM—decorin,3, 32, 33, 34 lumincan,3, 34, 35 biglycan,34, 36 fibromodulin,34, 35, 36 pe
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br Role of the funding source This
2020-07-29
Role of the funding source This work was supported by National Counsel of Technological and Scientific Development (CNPq); Foundation for Research Support of the State of Sao Paulo (FAPESP), Brazil (Grant number: 2010/07286-9). Conflict of interest Acknowledgments Introduction Corticotr
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