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By using the C elegans Matrisome Annotator tool we
2020-09-15
By using the C. elegans Matrisome Annotator tool, we found substantial enrichment for matrisome metabotropic glutamate receptor in these data sets. Thus, re-analyzing -omic datasets with the C. elegans Matrisome Annotator tool may be useful to generate novel hypotheses about the role of the C. eleg
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Present study observed failure of
2020-09-15
Present study observed failure of PPE usage by the majority of workers, which may be notable problem and may create a significant health effects due to pesticide exposure. Non-usage of PPE and its ill effects have been reported among farmers in Brazil [24,25] and Nepal [26]. It was reported that use
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The present study is the first time to
2020-09-15
The present study is the first time to investigate the effect of piperine on intestinal sterol transporters and enzymes in the small intestine. NPC1L1 is a sterol transporter responsible for taking up cholesterol from the lumen to enterocytes (Davis et al., 2004). ACAT2 is an enzyme, which esterifie
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We further verified the presence of CLIC CLIC and
2020-09-15
We further verified the presence of CLIC1, CLIC4 and CLIC5 in purified mitochondria following protocols described earlier (Singh et al., 2012). As shown in Fig. 4, CLIC4 and CLIC5 were present in the ultra-pure mitochondrial fraction (M3). All the three fractions obtained from 30% (v/v) Percoll grad
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Camptothecin br Results br Discussion Here we establish a ke
2020-09-15
Results Discussion Here we establish a key kinase cascade that acts at PCs to promote homolog pairing and synapsis. CHK-2 phosphorylates the zinc finger proteins that specify PCs, which, in turn, primes their recruitment of PLK-2 (Figure 7D). By recruiting these two kinases, PCs serve as signa
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Sampling sediments is usually performed
2020-09-15
Sampling sediments is usually performed with grab corers [16], [29]. The digested sludge analyzed by Ternes et al. [16] was taken directly from the digester and the activated sludge was obtained by Z-LEHD-FMK of the slurry of STPs [16]. Collected samples are transported under cooled conditions (+4 o
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The in vitro enantioselective metabolism of pesticides has
2020-09-14
The in vitro enantioselective metabolism of pesticides has been investigated by employing human liver microsomes, which are a reliable resource to perform MCL enantioselective risk assessment in humans (Carrão et al., 2019; de Albuquerque et al., 2018, 2016; Yao et al., 2016). The enantioselective m
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vegf inhibitor br RING type E s and their substrates There
2020-09-14
RING-type E3s and their substrates There is enormous diversity in substrate ubiquitination and its regulation, as the targets of RING-type E3s are incredibly varied. RING-type E3s are implicated as tumor suppressors, oncogenes, and mediators of endocytosis, and play critical roles in complex mult
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br Activity based probes br Characterization of coronavirus
2020-09-14
Activity-based probes Characterization of coronavirus-encoded DUBs with activity-based probes To study the activity of specific DUBs, investigators frequently take advantage of the ~10kDa (monoUb or Ubl ABP) or ~20kDa (DiUb ABP) increase in MW on probe labeling. SDS-PAGE analysis or blotting f
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Third we also found negative correlations between TREM mRNA
2020-09-14
Third, we also found negative correlations between TREM2 mRNA expression and the methylation rate of 4 CpG sites in the intron 1 of TREM2. Gene methylation rates are generally associated with gene expression. Thus, heavily methylated areas of genes are usually less active at the transcriptional leve
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The current study showed that the tested
2020-09-11
The current study showed that the tested nonselective COX inhibitors potentiated the neuronal (EFS) and endothelial (ACh)-dependent relaxation of rat corpus cavernosum. Indomethacin was the most effective among them in potentiating EFS-induced relaxation. Diclofenac was the most effective in potenti
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Erteberel sale While lowering the TID exposure of electronic
2020-09-11
While lowering the TID exposure of electronics is fairly straightforward, there are other Erteberel sale induced effects that are not as easily mitigated, especially with COTS components. Single Event Effects (SEE) occur when a high-energy particle strikes the active area of an integrated circuit,
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NPC L NPC Niemann Pick C
2020-09-11
NPC1L1 (NPC1 [Niemann-Pick C-like-1]-like intracellular cholesterol transporter) is the rate-limiting transmembrane transporter for cholesterol 4-DAMP from the intestinal lumen, and it mediates the absorption of both dietary and biliary cholesterol., , NPC1L1 is the target of the cholesterol-lowerin
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It remains unclear how LINE RNA
2020-09-11
It remains unclear how LINE1 RNA-Nucleolin-Kap1 are targeted to the Dux cluster. LINE1-Nucleolin-Kap1 may have other interacting partners with DNA binding specificity. For example, YY1 has been implicated in targeting a repressive complex containing Nucleolin to the human DUX4 cluster (Gabellini et
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Interestingly several ES cell lines are null for p
2020-09-11
Interestingly, several ES cell lines are null for p53, possibly because the EWS-FLI1 chimeric protein can directly and indirectly interfere with p53 activity [38], [39]. The inhibition, loss and/or mutation of p53, one of the most common events in tumorigenesis, results in a decreased oxygen consump
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