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The photocleaving properties of were
2020-10-27
The photocleaving properties of 1 were studied by performing ΦX174 photocleavage assays. Light irradiation of the mixtures of increasing amounts of 1 with supercoiled DNA caused>90% supercoiled form relaxation and approximately 5% of linearization for the higher concentrations of 1 (1:10bp and 1:2bp
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On the basis of the findings described above
2020-10-26
On the basis of the findings described above, a series of heterotricyclic analogs were designed and synthesized. The human CRF1 receptor binding and antagonist activity data for newly designed heterotricyclic core antagonists 28–33 are described in Table 3. Most of the tricyclic core analogs listed
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Other mutations in the SYNE region exons have been
2020-10-26
Other mutations in the SYNE1 3′ region (exons 81–85) have been implicated in an upper motor neuron disease, ARCA1 (Gros-Louis et al., 2007). The disease is characterized by progressive movement, coordination, and balance problems caused by disrupted Purkinje cell function and their impaired signalin
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Additionally although the membrane localized
2020-10-26
Additionally, although the membrane-localized ER signaling described in this review has generally been studied in isolation from nuclear signaling, it is becoming clearer and clearer that integration of these mechanisms must be considered (Frick, 2015). Perhaps the distinct estradiol signaling mecha
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To our knowledge immunohistochemical analysis for proGRP was
2020-10-26
To our knowledge, immunohistochemical analysis for proGRP was done in 5 cases [9], [10], [17], [18]. Takagi-Takahashi et al. reported that the tumor gyy synthesis were positive for proGRP in one case [9]. Yamaguchi et al. also showed that tumor cells in two patients of ES/PNET with elevated serum pr
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Other GPCRs notable for changes in expression on CLL
2020-10-26
Other GPCRs notable for changes in expression on CLL cells include upregulation of the thromboxane A2 receptor TBXA2R mRNA [61] and up and downregulation of mRNA and protein from the neurotensin receptors NTSR2 and NTSR1, respectively [62]. The Eμ-TCL1 mouse model of CLL has been used to study mult
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It was reported that the expressions of DPP
2020-10-26
It was reported that the expressions of DPP-4 and SDF-1α increase through HIF-1α [27], [28]. Myocardial ischemia by MI enhanced the DPP-4 and SDF-1α levels in myocardium in the present study. SDF-1α is released from cardiomyocytes and has beneficial effects on cardiomyocytes through SDF-1α/CXCR4 aft
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Collectively the results presented here provide new insights
2020-10-26
Collectively, the results presented here provide new insights into ligand binding, clustering, spatial distribution, and phosphorylation of DDR1b and DDR2 in response to soluble collagen I. As depicted in the cartoon of Scheme 1, we postulate a model in which the spatial distribution and assembly of
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As a basis for the DDR substrate identification
2020-10-26
As a basis for the DDR1 substrate identification approach detailed below, we first set out to perform 2D-gel electrophoresis with lysates isolated from collagen-stimulated human breast cancer MDA-MB-231 bradykinin receptor antagonist overexpressing DDR1 (b-isoform). This allowed us to determine whe
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Converging evidence suggests that reduced glutamate transmis
2020-10-26
Converging evidence suggests that reduced glutamate transmission in the LS is linked to increased anxiety-like behaviors (Radulovic et al., 1999, Henry et al., 2006, Bakshi et al., 2002, Liu et al., 2004). Therefore, attenuated CRF1 receptor-mediated excitatory transmission in the LS following ASV-t
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br Bipartite graph br Algorithm for CFC
2020-10-26
Bipartite graph Algorithm for CFC Error detection rate and overhead evaluation Test results and discussion For verifying the proof in Irinotecan from the perspective of practice, this section brings tests and analysis based on the onboard computer (OBC) of the in-service ZDPS-1A pico-sat
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br Study design br Results
2020-10-26
Study design Results To explore potential differences in the volume the different swabs absorb, the loss of weight of tubes filled with water after soaking the different swabs under defined conditions was determined. This revealed that the different swabs absorbed between approximately 0.07 an
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br Materials and methods br Results br
2020-10-23
Materials and methods Results Discussion The EP4 Gastrodin synthesis for PGE2 is similar to the EP1, EP2 and EP3 receptors in that they all have seven transmembrane segments and are coupled to Gα subunits of heterotrimeric G proteins, with a different Gα subunit for each receptor (Sugimoto
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Eggs have been recognized as an important contributor of fun
2020-10-23
Eggs have been recognized as an important contributor of functional ingredients for humans [3]. Egg yolk is composed of various biologically active proteins. The water-soluble proteins of egg yolk have been examined for their functional effects on longitudinal bone growth during the growth period in
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br Experimental Procedures br Author Contributions br Acknow
2020-10-23
Experimental Procedures Author Contributions Acknowledgments Research in the Davis laboratory was supported by grants 4R37NS019904, 5R01NS052351, and 1R35NS097224 from NINDS. Research in the Martemyanov laboratory was supported by grants DA036596 and DA026405 from NIDA, and MH105482 from NI
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