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In the past years the role of the CD adenosinergic
2024-05-22
In the past 10 years, the role of the CD73-adenosinergic pathway in suppression of anti-tumor immunity has increasingly been recognized [13], [14]. In this review, we discuss the latest findings dealing with the regulation of anti-tumor immunity by CD73 and adenosine. We also discuss ongoing clinica
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AS 101 br Roles for GMF in Endocytic Traffic
2024-05-22
Roles for GMF in Endocytic Traffic In addition to its roles in cell migration, GMF regulates actin-dependent endocytosis in yeast and mammals 13, 14, 50, and promotes the turnover of focal adhesions in immune AS 101 42, 51. Vinculin, a central component of focal adhesions that anchors cells to t
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br Thymic expression of AChR
2024-05-22
Thymic expression of AChR Both linear unfolded epitopes of AChR subunits and the intact AChR are avidly expressed in thymus, particularly by thymic epithelial cells and myoid cells [17], [18], [19]. AChR-antibody positive MG patients often show thymic hyperplasia, characterized by lymphoid follic
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Heparin sodium br Cytochrome b br Cytochrome P hydroxylase
2024-05-21
Cytochrome b5 Cytochrome P450 17α-hydroxylase/17,20-lyase (P450 17A1) A number of P450s involved in steroid biosynthesis are multifunctional as they carry out two or more sequential hydroxylation reactions on the same substrate(s). P450 17A1 is a dual function endoplasmic reticulum enzyme enco
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Autotaxin has been linked to chemoresistance through its
2024-05-21
Autotaxin has been linked to chemoresistance through its ability to inhibit apoptosis induced by paclitaxel in breast cancer NPPB [15] and LPA can inhibit cell death induced by cisplatin [40]. Autotaxin was included in the present study because it was identified as being over-expressed in patients
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Autophagy is finalized through the coordinated positioning
2024-05-21
Autophagy is finalized through the coordinated positioning and fusion of autophagosomes with lysosomes, during which an array of common and specific membrane traffic-associated proteins is mobilized. Among these proteins, small GTPases, like Rab7, Rab34, or Arl8, and their AT7519 australia proteins
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and LO are members of the lipoxygenase family
2024-05-21
5- and 12/15-LO are members of the lipoxygenase family that convert arachidonic Bradykinin acetate into lipid mediators such as leukotriene B4 (LTB) and 12()-hydroxyeicosatetraenoic acid (HETE) and 15()-HETE, respectively. Evidence from several in vitro and in vivo studies has shown that activation
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br Perspective AA LA and other PUFAs and their lipid
2024-05-21
Perspective AA, LA and other PUFAs and their lipid metabolites play an important role in human diseases. 12/15-LOX which is the metabolic enzyme of them plays an important role in the pathogenesis-related diseases such as atherosclerosis, diabetic nephropathy, neurological diseases and other path
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Furthermore low affinity sites that share
2024-05-21
Furthermore, low-affinity sites that share no structural homology with the aforementioned sites have been described in the transmembrane domain. It has been discovered that, in α1βγ2 receptors, potentiation of GABA-activated currents by high concentrations of diazepam is biphasic, with a high- and
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Thirdly and finally multiple studies have analyzed the activ
2024-05-21
Thirdly and finally, multiple studies have analyzed the activation of neurons in the auditory telencephalic areas of songbirds in response to various auditory stimuli. Neuronal activation was identified by the increased expression of immediate early genes such as fos or ZENK (also know as zif-268, e
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Placental cells also express P aromatase CYP A encoded by
2024-05-21
Placental cells also express P450 aromatase (CYP19A1, encoded by CYP19A1). In the placenta, this enzyme requires an external source of androgens, provided by the adrenal gland of the fetus, to form estrogen. The fetal adrenal gland produces dehydroepiandrosterone (DHEA) [9] and, in the placenta, it
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A next series of experiments explored whether cardiac
2024-05-21
A next series of experiments explored whether cardiac Ampkα1 Sirolimus is modified in response to pressure overload imposed by TAC. As a result, 2weeks of TAC treatment significantly increased Ampkα1 protein abundance in cardiac tissue from Ampkα1+/+ mice as compared to sham treated mice (Fig. 6A).
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The current results also demonstrated tendencies toward
2024-05-21
The current results also demonstrated tendencies toward decreased serum Aβ40 levels and increased Aβ42 levels during the 1-year follow-up. These tendencies are consistent with the results of a previous study that evaluated Aβs in the CSF of patients with late-life depression (Pomara et al., 2016). T
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The first and the best characterized
2024-05-21
The first and the best-characterized mechanism of receptor-dependent internalization of Aβ is mediated via the α7-nicotinic wst-1 receptor [82]. Lipoprotein receptor protein represents the second best-studied route that facilitates the uptake of Aβ by neurons, involving additional molecules such as
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In summary our data have shown that
2024-05-21
In summary, our data have shown that one mechanism by which glucose may mediate monocyte–endothelial cell interaction in the retinal endothelial cells is via the 12/15-LO pathway Furthermore, our current and previously published data [20,22] indicate a differential role of endothelial 12/15-LO versu
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