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4-iodo-SAHA We recently reported that the information about
2021-01-11
We recently reported that the information about the electronic density obtained from a QTAIM analysis is useful to describe the molecular interactions that stabilize and destabilize the different complexes L-R [13], [14], [15]. Specifically in our previous work reported for DHFR inhibitors, the QTAI
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br The role of chemokine and AD Chemokines
2021-01-11
The role of chemokine and AD Chemokines are small cytokine proteins that are involved in various immunological and physiological functions. These proteins can be involved in cell migration and localization during homeostasis and inflammation, and as such, they were named chemokines [80]. Chemokin
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In summary the reduction of one or more pro
2021-01-11
In summary, the reduction of one or more pro-inflammatory cytokines, such as TNF-α, IL-1β, IL-6, IL-8 was observed in almost all the monoterpenes studied. Increased levels of the anti-inflammatory cytokine IL-10 was shown to play a prominent function in the anti-inflammatory effect of monoterpenes,
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Although the crystal structures of Atg C and
2021-01-11
Although the crystal structures of Atg4C and Atg4D are not available, their three dimensional structures can be acquired by homology modeling, using the structure of Atg4B as a template (Zhang, Li, Ouyang, Liu, & Cheng, 2016). In that model, the catalytic triad is conserved (Cys110/Asp345/His347 for
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br Methods br Results The characteristics of
2021-01-11
Methods Results The characteristics of the 20 control subjects and 63 patients stratified by SDB severity, matched for age, sex, and BMI z-score, are described in Table 1. As expected, AHI, OAI, ODI, and SLT90% increased and SpO2 decreased progressively with the severity of the disease. Dis
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Previous studies from our laboratory have demonstrated that
2021-01-11
Previous studies from our laboratory have demonstrated that CysLT1R mRNA and protein expression can be upregulated by T2-type cytokines (IL-13, IL-4, and IL-5) in monocytes, macrophages, and eosinophilic HL-60 cells., To our knowledge, however, there are no studies on interactions of cytokines (suc
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Tioconazole P has three subfamilies CYP CYP
2021-01-11
P450 has three subfamilies (CYP1, CYP2, and CYP3), which contribute largely to the oxidative biotransformation of xenobiotics that include most drugs, dietary chemicals, and environmental pollutants. The CYP1 enzymes have great importance in the bioactivation of mutagens and its isoforms are capable
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Perturbation in the cytokine network is correlated with
2021-01-11
Perturbation in the cytokine network is correlated with disruption of growth hormone and glucocorticoid (GC) homeostasis (Thissen and Verniers, 1997; Sahid El-Radhi et al., 2000; Waxman and Holloway, 2009; Zhao et al., 2014), with important physiological consequences because cytokines affect the reg
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The sequence identity of CYP
2021-01-11
The sequence identity of CYP3A163 with CYP3A sequences from other species is maximum in reptiles ranging (75-91)%, gradually decreasing from p53 inhibitor (63-71)% to mammals 62% to downwards based on evolutionary distances. The high level of homology with CYP3A77 in Alligator mississippiensis sugg
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Three dimensional conformational changes in the cargo protei
2021-01-11
Three-dimensional conformational changes in the cargo protein’s NES, caused by protein phosphorylation, dephosphorylation, or mutation, can regulate CRM1 binding (Craig et al., 2002, Vogt et al., 2005). Additional protein modifications such as sumoylation, ubiquitination, acetylation, and/or the bin
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Nucleocytoplasmic transport systems play a critical
2021-01-11
Nucleocytoplasmic transport systems play a critical role in intracellular localization and regulation of proteins in each cell. This balance is quite important and is typically uncontrolled in cancer cells. Specific localization of tumor suppressor and oncoproteins is quite important because any abn
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Phos-tag This work aimed to investigate whether the increase
2021-01-11
This work aimed to investigate whether the increase in liver lipid depots, observed in the fetuses from rats fed a saturated-fat-rich diet, persists later in life in the offspring (a) at 21days of age immediately after weaning and (b) at 140days of age, after healthy nourishing. Furthermore, we want
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It was recently reported that a functional
2021-01-11
It was recently reported that a functional single nucleotide polymorphism (rs75932628) within Triggering receptor expressed on myeloid ribosomal s6 kinase 2 (TREM2) is associated with AD (Guerreiro et al., 2013). Homozygous loss of function mutations in TREM2 are also associated with an autosomal r
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Another significant finding in our study was the demonstrati
2021-01-11
Another significant finding in our study was the demonstration that the axon-protective action associated with CK2 inhibition correlated with preservation of mitochondrial structure and function in Caspase-9 Colorimetric Assay Kit (Fig. 11). Because of the consistent protection conferred by CK2 inh
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The acid base properties of the IL are
2021-01-11
3. The acid-base properties of the IL are important issues to consider because protonation changes caused by Brønsted-acidic or basic ions may result in enzyme deactivation [29]. Thereby, the acid-base properties of the newly designed IL need proper control for enzymes by selection of appropriate ca
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