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Enhanced responses to varying concentrations of
2021-07-19
Enhanced responses to varying concentrations of bronchoconstrictors, such as MCh, and airway obstruction are characteristic of Clodronate Disodium and common to other clinical states, including chronic obstructive pulmonary disease, lung transplantation, and infection- or chemical agent-induced airw
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CYP contributes to the metabolism of more than
2021-07-19
CYP450 contributes to the metabolism of more than 90% of currently available drugs (Shapiro and Shear, 2002). Currently, CYP1A is the most studied xenobiotic-metabolizing isoform in fish and is often used as a biomarker for early effects of pollutants in aquatic organisms (Havelkova et al., 2007). T
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Experimentally measured DGAT activity was
2021-07-19
Experimentally measured DGAT activity was first reported by Weiss et al. (1960) and several different types of DGAT enzyme have since been described in plants [12,41,42]. As recently as 2011 there appeared to be just two DGAT enzymes both in plants and in other eukaryotes, namely DGAT1 and DGAT2 [43
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RNA sequencing RNA seq is a particularly effective
2021-07-19
RNA-sequencing (RNA-seq) is a particularly effective technology for gene discovery in a given process, especially in non-model species for which reference genome sequences are not available. Although the major application of RNA-seq analyses is the identification of differentially expressed genes (D
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Application of the CPH model relies on the assumption that
2021-07-19
Application of the CPH model relies on the assumption that the hazard ratio of two observations is constant over time [2]. This enables us to infer the rate of risk of the treatment. For example, in the study of patients with pulmonary arterial hypertension (PAH) [5], the hazard ratio of a group of
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Materials and methods br Results
2021-07-19
Materials and methods Results Discussion Microbial production of trans-4Hyp, an added-value amino reverse transcriptase for pharmaceuticals, offers significant advantages over conventional chemical extraction in economic and environmental aspects. However the low titer and productivity with t
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br Study design br Results We enrolled subjects
2021-07-19
Study design Results We enrolled 50 subjects awaiting SOT (15 kidney, 14 liver, 1 liver + small bowel, 11 lung, 9 heart) and 50 controls (Table 1) who were similar with respect to median age (subjects 49.1 yrs., controls 48.6 yrs.) gender (64% male subjects and controls), and CMV-seropositivit
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IOX2 Finally we have determined for the first time that
2021-07-19
Finally, we have determined for the first time that aromatase enzyme activity is necessary to observe IGF-1-dependent IOX2 receptor activation. Neuroestrogen synthesis has been shown to be important for the maintenance of synaptic spine density in hippocampal slice cultures (Kretz et al., 2004) and
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Current therapeutic protocols in OS and ES
2021-07-19
Current therapeutic protocols in OS and ES consist of neoadjuvant chemotherapy and local surgical resection, followed by adjuvant chemotherapy. These treatments lead to a 70% overall survival for localized disease but can decrease to 15% in case of metastasis. With CS being resistant to conventional
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br Substrate characterization of candidate peptide reporters
2021-07-19
Substrate characterization of candidate peptide reporters in a library Measurement of resistance to intracellular proteases Use of capillary zone electrophoresis for assay readout Selection of lead peptide from small library screen Characterization of final reporter Additional modif
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br Materials and methods br Results and discussion br Conclu
2021-07-19
Materials and methods Results and discussion Concluding remarks Together, the results of the theoretical kinetic simulations and of the analysis of the experimentally determined kinetic data of SoBADH performed in this work show that ignoring substrate inhibition causes potentially importan
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Even more unambiguous was the relative contribution of Gq
2021-07-17
Even more unambiguous was the relative contribution of Gq/11 signaling in AngII-mediated transactivation as measured by the ERK1/2 and the BRET-based readout. Although Gq/11 was absolutely required for ERK1/2 phosphorylation following AngII-stimulation, in contrast, we observed a sustained EGFR-Grb2
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A growing number of other post translational modifications a
2021-07-17
A growing number of other post-translational modifications are implicated in regulation of the ubiquitin system, including substrate modification by hydroxylation, glycosylation, acetylation, methylation, modification by poly(ADP-ribose) (PAR), and attachment of ubiquitin-like modifiers. The HIF1-α
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In conclusion we propose that
2021-07-17
In conclusion, we propose that UBE2T (FANCT) mutations define a FA subtype. This is also a rare example of a mutated E2 enzyme causing an inherited human disorder, like UBE2A. The p.Gln2Glu substitution is probably hypomorphic, as indicated by the fact that a siUBE2T knockdown made AP65P-hTERT ddhUT
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pramiracetam br Results br Discussion Adult hand foot and mo
2021-07-17
Results Discussion Adult hand, foot and mouth disease gets no particular research interest because it has been seen as a sporadic mild viral infection that spontaneously resolved in a few days. However, evidence showed that adults may act as latent enterovirus reservoirs. A serum epidemiologic
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