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br Activity dependent control of myelination and
2021-10-08
Activity-dependent control of myelination and myelin maintenance Oligodendrocytes have intrinsic myelinating capacity and can myelinate fixed retinoic acid receptor in addition to synthetic nanofibers and micropillars [21, 34, 35]. What prevents oligodendrocytes from myelinating dendrites or oth
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Typically upon chronic agonist exposure GPCRs undergo desens
2021-10-08
Typically, upon chronic agonist exposure GPCRs undergo desensitization and internalization resulting in a loss of receptor responsiveness over time (Drake et al., 2006, Kelly et al., 2008). However, not all GPCR systems conform to this model of acute agonist-mediated regulation. Some receptors have
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In humans the effect of GnRH and hCG on
2021-10-08
In humans, the effect of GnRH and hCG on trophoblast invasion was found to be mediated through extracellular matrix remodeling by facilitating the activity of MMP2 and MMP9 [13], [18], [44]. Both ampk inhibitors are collagenases that degrade extracellular matrix. In canines, this has not yet been i
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br Results br Discussion Arc
2021-10-08
Results Discussion Arc1p forms a ternary complex with ScMetRS and ScGluRS and acts as a tIF in trans of both synthetases to improve their catalytic efficiencies.20., 24. The human homolog of Arc1p, the p43 protein, is associated within a multi-enzyme complex containing nine aminoacyl-tRNA synt
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In order to elucidate the reasons
2021-10-08
In order to elucidate the reasons of high efficacy of , we evaluated the BOC group itself and the linkage between the BOC group and the benzene ring of A-part. Urea moiety (), the replacement of an oxygen Ipratropium Bromide of the BOC group to a nitrogen atom, decreased the activity (EC = 0.12 μM)
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The structural modelling studies gave a view of arsenic medi
2021-10-08
The structural modelling studies gave a view of arsenic mediated covalent modifications possible in Cx43. In order to look for the biochemical effects of Arsenic on Cx43 and Cx43 mediated GJIC formation, and in order to further decipher the mechanism involved in Arsenic induced decreases in expressi
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In general substrates that undergo regulated intramembrane
2021-10-08
In general substrates that undergo regulated intramembrane proteolysis are initially cleaved in the extracellular domain by sheddases such as TACE (TNFα converting enzyme) or ADAM (a disintegrin and metalloproteinase domain)/α-secretase, or by aspartyl proteases, such as BACE/β-secretase, before cle
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Regulation of FGF signalling is
2021-10-07
Regulation of FGF signalling is critical to ensure a balanced response to receptor stimulation. This occurs largely through negative feedback mechanisms, including receptor internalisation via ubiquitination (Wang et al., 2002) and induction of negative regulators, for example SPRY, SPRED 1 and 2 an
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br Introduction Isoprenoid structures play an essential role
2021-10-07
Introduction Isoprenoid structures play an essential role in biology and over 30,000 natural products of this class are known (Greenhagen et al., 2003). Like other animals, insects require these compounds for many disparate processes, including electron transport (e.g., ubiquinones), protein glyc
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br Conclusions According to our results we may
2021-10-07
Conclusions According to our results we may suggest that FAS c.-671AG salubrinal sale or G allele and FASLG gene c.-844T allele were not to be a risk factor, whereas FASLG gene c.-844TC genotype may be protective in the studied Turkish population. Because of the limited sample size in this study
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br Expression and Purification of LSD
2021-10-07
Expression and Purification of LSD1 Proteins In Vitro Enzymatic Assays Analysis of LSD1 Demethylase Activity Acknowledgments Conflict of Interest Statement: Y.S. is a cofounder of Constellation Pharmaceuticals, Inc. and is a member of its scientific advisory board. Y.S. is also a consu
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In NAFLD models the first hit is liver fat accumulation
2021-10-07
In NAFLD models, the “first hit” is liver fat accumulation, which causes insulin resistance, whereas the interplay of inflammatory cytokines, which causes inflammation, acts as the representative “second hit” [9]. However, recently, the “multiple hit” hypothesis has taken into consideration that mul
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Introduction Histone is the core
2021-10-07
Introduction Histone is the core component of chromatin and histone modification is one of the key mechanisms of epigenetic regulation (Bannister and Kouzarides, 2011). Amino CHIR-090 residues on histone tails can be modified under different mechanisms including acetylation, methylation, phosphory
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br Acknowledgements This work has been supported by
2021-10-07
Acknowledgements This work has been supported by TSTAR USDA and Florida Citrus Advanced Technology Program Grants to D.B., C.P and R.S. One of us (D.B.) is an established scientist fellow at the Oak Ridge Institute for Science and Education (ORISE). This research was supported in part by an appoi
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Introduction Soluble guanylyl cyclase sGC is a key protein
2021-10-07
Introduction Soluble guanylyl cyclase (sGC) is a key protein in the regulation of multiple physiological functions in mammalian physiology [1,2]. Upon stimulation by nitric oxide (NO) [3], sGC generates cyclic guanosine monophosphate (cGMP) from guanosine-5′ triphosphate and activates protein kinas
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