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Focal adhesion kinase FAK also known
2021-11-03
Focal adhesion kinase (FAK), also known as protein tyrosine kinase2 (PTK2), is a tyrosine kinase and vital member in integrin-mediated signaling pathways [3]. In response to integrin involvement, FAK would be phosphorylated. It was reported that FAK is involved in cellular adhesion and spreading [4]
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Previous studies have shown that ox LDL induced hepatic
2021-11-03
Previous studies have shown that ox-LDL-induced hepatic sinus dysfunction is the result of multiple pathways, multi-factorial regulation, and in the present study, we reported for the first time that ox-LDL regulates the basement membrane protein VN through the integrin αvβ5 pathway under high gluco
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sr1 Our data show that oxidative stress high levels
2021-11-03
Our data show that oxidative stress (high levels of ROS) suppresses the process of lysosomal exocytosis, which would be predicted to impair the expulsion of toxic compounds from cells. Therefore, we propose that ROS have a biphasic effect on the lysosomal clearance: consistent with their role as a s
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br S Nitrosoglutathione reductase GSNOR also identified as g
2021-11-02
S-Nitrosoglutathione reductase (GSNOR) also identified as glutathione-dependent formaldehyde dehydrogenase (FDH), is a zinc-dependent dehydrogenase. It is a member of the alcohol dehydrogenase (ADH) family and is called class III alcohol dehydrogenase that regulates the levels of S-nitrosothiols (
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br Discussion Agonist and antagonist
2021-11-02
Discussion Agonist and antagonist action at the GluN1/GluN3 ddhC is known to be complex [4], [10]. Recombinant GluN1/GluN3 receptors produce only small excitatory currents in response to glycine, likely because of a combination of activation via GluN3 and desensitization via GluN1 [2], [3], [11]
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It is known that hypercapnia
2021-11-02
It is known that hypercapnia, as well as hypoxia, can result in a decrease in body temperature, but the mechanisms involved are not very well known (Barros and Branco, 1998; Saiki and Mortola, 1996). One TNF-alpha, recombinant rat protein is that when there is an acute hypercapnic exposure, acidosi
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br Materials and methods br Results br Conclusions
2021-11-02
Materials and methods Results Conclusions We developed a glutamate biosensor with chitosan as a matrix for the immobilization of the enzyme glutamate oxidase on the surface of a platinum electrode. Our miniaturized biosensor of 50 µm in diameter can be applied for monitoring glutamate in vi
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BAY 41-8543 br Materials and methods br
2021-11-02
Materials and methods Results Discussion The glucose transporter GLUT1 can be acutely activated or inhibited in L929 fibroblast BAY 41-8543 by a wide variety of reagents or nutrient conditions [[9], [10], [11], [12],36,50]. This abrupt change in the activity of GLUT1 occurs within minutes
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Introduction Glucocorticoids are released in response
2021-11-02
Introduction Glucocorticoids are released in response to stress and play an important role in inflammation, cellular growth, development, body fluid homeostasis, carbohydrate, lipid, and protein metabolism. However, circulating glucocorticoid excess has been associated with a classical phenotype of
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Aclacinomycin A br Acknowledgements br Introduction Ghrelin
2021-11-02
Acknowledgements Introduction Ghrelin is a potent orexigenic hormone and growth hormone secretagogue mainly derived from the stomach [1], [2], [3], [4], [5]. Other pleiotropic actions of the hormone include those that are glucoregulatory, food reward-enhancing, gastric motility-enhancing, and
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The ultimate success of multimodal probe
2021-11-02
The ultimate success of multimodal probe in the inflammation imaging will be dependent on simplicity in synthesis (combining various modules without protection/deprotection), ease of optimization of pharmacological properties (linker group with tunable PEG moiety), co-registration of macroscopic and
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In the phylum Cnidaria which separated from the main line
2021-11-02
In the phylum Cnidaria, which separated from the main line of Metazoa early during evolution, FGFR signaling is essential during development and morphogenesis. Two FGFRs and two FGFs antagonistically control formation of the apical organ in the anthozoan Nematostella and target the MAPK pathway (Ren
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br General features of FGFRs and
2021-11-02
General features of FGFRs and inhibitors Conclusion Given the critical role of FGFRs in the progression of tumors, the co-crystal structures of these kinases in complex with inhibitors are determined in order to clarify the mechanism of actions and explore new efficient inhibitors. This manusc
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To validate that our natural experiment operates
2021-11-02
To validate that our natural experiment operates primarily through a large negative shock to the risk-taking incentives provided by option compensation measured by vega, we do two sets of tests. First, we confirm a significant drop in vega after the adoption of FAS 123R for treated firms relative to
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Sodium Orthovanadate sale br Materials methods br Results
2021-11-02
Materials & methods Results FAS c.-671AA, AG and GG genotypes and A and G Sodium Orthovanadate sale frequencies were similar in both patients with FMF and healthy control groups, and no significant difference was found (P>0.05, Table 1). The frequency of TC genotype in FASLG in the healthy con
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