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In our study the changes in the and subunit expression
2022-01-17
In our study, the changes in the α4 and δ subunit expression were accompanied by a significant increase in γ2 subunit expression in almost all analysed hippocampal structures in the fully kindled animals. In contrast, an acute injection of PTZ at a convulsive dose (55mg/kg) evoked a potent decrease
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br Role of FPRs in Cancer br Concluding Remarks Activation
2022-01-17
Role of FPRs in Cancer Concluding Remarks Activation of FPRs by formylated bacterial peptides or by host-derived mitochondrial peptides is required for local control of infection and wound healing. Nevertheless, various detrimental effects can result from the release of formylated peptides int
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Fibroblast growth factor receptors FGFRs
2022-01-17
Fibroblast growth factor receptors (FGFRs) play an essential role in the regulation of cell survival, proliferation, migration and differentiation. FGFRs are a family of receptor tyrosine kinases (RTKs) exhibiting an extracellular immunoglobulin (Ig)-like ligand binding domain, a transmembrane domai
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Introduction Type diabetes T D has been seriously
2022-01-17
Introduction Type 2 diabetes (T2D) has been seriously affecting the health life of 415 million people and 193 million undiagnosed people [1]. Importantly, this disease was found to cause death at least 1.5 million annually, and has brought about an extensive health concern throughout the world [2,3
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Taken together our studies uncovered
2022-01-15
Taken together, our studies uncovered that the RP215 antibody recognize a novel CIgG molecule N-glycan modification at a non-consensus site within the CH1 domain expressed in LSCC tumors. RP215-CIgG interacts with the integrin α6β4 complex and the unique N-glycan epitope mediates the activation of d
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br Materials and methods br Results
2022-01-15
Materials and methods Results and discussion To analyze the dependence of lysosomal exocytosis on Cu we exposed HeLa sodium butyrate to fresh buffer containing normal levels of free Ca (1mM) and measured β-hex levels in the extracellular medium, followed by measuring β-hex content in the tota
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As the presence of HPV
2022-01-15
As the presence of HPV-specific Novobiocin Sodium sale at time of vaccination is related to antibody response to vaccination [28], we evaluated its influence on the antibody responses among HIV+ and HIV− individuals at Months 7 and 18. Despite the small numbers, we observed that HIV+ men with detect
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HPgV coinfection has been associated with reduced
2022-01-15
HPgV coinfection has been associated with reduced liver disease in HPgV/HCV/HIV triply infected patients (Barbosa Ade et al., 2009, Berzsenyi et al., 2007, Berzsenyi et al., 2009, Berzsenyi et al., 2011). It is possible that HCV NS3 protease inhibitors could inhibit HPgV replication diminishing its
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Using RT PCR we demonstrated the expression of
2022-01-15
Using RT-PCR we demonstrated the expression of GPR55 receptor mRNA in the ileum and colon of mice, which is in good agreement with previous reports (Lin et al., 2011). The quantitative analysis showed the abundance of GPR55 mRNA in the mucosa of the ileum and colon. In contrast, in LMMP preparation
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Alpha synuclein AS is a
2022-01-15
Alpha synuclein (AS) is a protein located in presynaptic terminals of neurons that functions in recycling and storage of neurotransmitters [17]. Under conditions of inflammation and oxidative stress, AS proteins misfold and accumulate into ci-1033 [81], [90]. The aggregates of misfolded AS oligimor
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Another group of secreted proteins that determine the virule
2022-01-15
Another group of secreted proteins that determine the virulence of V. dahliae are effectors and microbe associated molecular patterns (MAMP) that regulate plant immunity [10]. So far, there is only one hiv protease inhibitors gene Ave1 cloned in V. dahliae, yet it does not exist in race 2 strains s
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br Materials and methods br Results br Conclusions
2022-01-15
Materials and methods Results Conclusions We developed a glutamate biosensor with chitosan as a matrix for the immobilization of the enzyme glutamate oxidase on the surface of a platinum electrode. Our miniaturized biosensor of 50 µm in diameter can be applied for monitoring glutamate in vi
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Due to the requirement of
2022-01-15
Due to the requirement of high-end methods such as total internal reflection fluorescence (TIRF) microscopy to visualize lipid rafts, isolation procedures are employed to study the protein content of lipid rafts [29]. The different methods utilized to isolated lipid rafts and other low density micro
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Indeed our immunohistochemical analysis of
2022-01-15
Indeed, our immunohistochemical analysis of skin tissue samples without any pathology confirmed the expression of MR and GR. Extending earlier findings in rats (Shaqura et al., 2016a, Shaqura et al., 2016b), we demonstrate here that MR mainly colocalize with the nociceptive neuronal marker CGRP sugg
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Introduction Glucose dependent insulinotropic polypeptide
2022-01-15
Introduction Glucose-dependent insulinotropic polypeptide (GIP) is a hormone secreted postprandially from enteroendocrine K cells in response to ingestion of either fat [1], protein [2], or carbohydrates [3]. GIP is primarily known for its glucose-dependent insulinotropic actions mediated via the G
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