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br Cell origin The ontogeny of astrocytes in vitro
2022-03-25
Cell origin The ontogeny of astrocytes in vitro has been investigated in detail; Raff et al. (1983) characterised two types of astrocytes: type 1 being fibroblast-like in morphology and poorly labelled with a monoclonal antibody (AB25), whereas type 2 exhibited oligodendrocyte or neuron-like morp
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With the advent of genome sequencing hexokinase
2022-03-25
With the advent of genome sequencing, hexokinase gene sequences are now available from a far greater number of vertebrate species, as well as from diverse non-vertebrate animal species. As indicated above, searches of vertebrate genome sequences revealed the existence of a novel fifth member of the
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br Experimental br Acknowledgments This project
2022-03-25
Experimental Acknowledgments This project was generously supported by Grünenthal GmbH and IECB. We also thank the staff members of the technical platform of IECB and Grünenthal GmbH for their availability and their skills. Introduction Glucocorticoids (GCs) are essential steroid hormones t
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Glucagon was described as an insulin secretagogue as early
2022-03-25
Glucagon was described as an insulin secretagogue as early as 1965 (Samols et al., 1965). Our studies extend these findings by demonstrating that this is a direct effect mediated by distinct receptors in the mouse pancreas. Previous experiments on isolated β Salirasib clearly show that glucagon is
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Attempting to further elucidate the
2022-03-25
Attempting to further elucidate the role of Quinupristin-Dalfopristin Complex mesylate and activation of the Gcgr without the influence of GLP-1, we used DT-Gcg mice with acute knockdown of all proglucagon products. This mouse model has previously been shown previously to have a normal total islet
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br Methods br Results br
2022-03-25
Methods Results Discussion In this study, we investigated temperature effects on Vj-gating properties of two cardiac GJs. In the case of Cx45 GJs, increased temperature from 22 °C to 28 °C (or 32 °C) led to an accelerated Vj-dependent deactivation with little change in the extent of Vj-gati
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The orientation of the immobilized enzyme may affect
2022-03-25
The orientation of the immobilized enzyme may affect its activity and stability and therefore the final biocatalyst performance. Since proteins present areas more prone to unfolding in their surface or near to it [36], the immobilization through these areas may improve the final biocatalyst stabilit
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D appears to be important for receptor function as a
2022-03-25
D83 appears to be important for receptor function as a mutation to an alanine produced a non-functional channel. Interestingly, maintaining the charge as in D83E produced only a small reduction in GABA sensitivity. Other mutations at this position which included residues capable of hydrogen bonding
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Reducing the molecular weight According to a thorough analys
2022-03-24
Reducing the molecular weight: According to a thorough analysis of a large, structurally diverse Caco-2 permeability dataset using a variety of statistical techniques by AstraZeneca researchers, logD and molecular weight are suggested the most important factors in determining the permeability of dru
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Immunohistochemical analysis of sheep skin sections
2022-03-24
Immunohistochemical analysis of sheep skin sections showed that sGC prtotein is expressed in the hair follicles with different location and abundance between white and black sheep skin (Fig. 6). In white sheep skin, Strong sGC positive signal was detected in the upper hair dermal papilla but no posi
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Cells undergoing EMT display a downregulation of E
2022-03-24
Cells undergoing EMT display a downregulation of E-cadherin and dissociation of their junctional complexes that associates cell-cell contacts with the 8602 sale cytoskeleton, known as the adherens junction (Berx and van Roy, 2009, Birchmeier and Behrens, 1994). Adherens junctions are specialized ce
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br Results and discussion br Conclusion In summary starting
2022-03-24
Results and discussion Conclusion In summary, starting from our previous lead GANT 58 mg 1, we replaced the 5-nitropyrimidine core with pyrimidopyrimidine to obtain a series of novel compounds as drug candidates of GPR119 agonist for treatment of type 2 diabetes. Some derivatives showed good a
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Experimental section br Results and discussion br Conclusion
2022-03-24
Experimental section Results and discussion Conclusion In summary, we have developed a fluoresence method to sensitively detect hAAG on the basis of TdT-activated Endo IV-assisted hyperbranched amplification. This method shows the following advantages: (1) the combination of TdT-mediated exte
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Ginger derived glycoproteins contain a variety of
2022-03-24
Ginger-derived fbpase contain a variety of functional components, including specific phenolic compounds, purine compounds, and bioactive polysaccharides. Moreover, glycoproteins belong to the glycoconjugates, which combine some of the properties of polysaccharides and proteins. It has been reported
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A pooled overall survival analysis at year showed no differe
2022-03-23
A pooled overall survival analysis at 1year showed no difference in survival between the two study arms, although these studies were not designed or powered to demonstrate a survival benefit. Among the 979 total patients in both ROMANA 1 and 2, about 55% continued on to the ROMANA 3 trial. That tria
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