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Several enzymes in serine and
2022-11-04
Several enzymes in serine and glycine metabolism have been proposed as biomarkers for cancer stage and prognosis. Phosphoglycerate dehydrogenase (PHGDH), phosphoserine phosphatase (PSPH), and serine hydroxymethyltransferase (SHMT) levels are high in TNBC and low in luminal-A breast cancers (Kim et a
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The direction of glutamate transport by the cell membrane
2022-11-04
The direction of glutamate transport by the cell membrane transporter is reversible. As mentioned above, glutamate transport is an electrogenic process associated with a transmembrane ion gradient established by the Na+-K+ pump through hydrolysis of adenosine triphosphate. Under conditions of energy
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PNU 37883 hydrochloride AdipoR and AdipoR have been reported
2022-11-04
AdipoR1 and AdipoR2 have been reported to be present in almost all type of tissues and low PNU 37883 hydrochloride levels have been observed in white adipose tissue (Inukai et al., 2005). These receptors have been observed to become deregulated with the onset of obesity, resulting in a reduced leve
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It is worth mentioning that cordycepin as an adenosine
2022-11-04
It is worth mentioning that cordycepin, as an adenosine analogue, is structurally similar to adenosine. A previous study has shown that the anti-apoptotic effects of cordycepin are partially dependent on the activation of A1R [16], and cordycepin increases theta waves power density via nonspecific a
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EIPA The pathogenesis of d penicillamine induced MG is
2022-11-04
The pathogenesis of d-penicillamine-induced MG is not clear. The repertoire of anti-AChR EIPA in d-penicillamine-induced MG has been shown to be similar to that in idiopathic MG in terms of AChR antigenic regions, suggesting a common immune mechanism (Tzartos et al., 1988). About 20% of d-penicilla
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We conducted the largest drug screen
2022-11-04
We conducted the largest drug screen to date in HPV-positive cancers and identified Aurora kinase inhibitors as effective and understudied drugs in HNSCC and CESC. These drugs cause apoptosis and cell cycle arrest in vitro and decrease tumor size in vivo. This is the first published study to demonst
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In glucose stimulated pancreatic cells B Raf activity is
2022-11-03
In glucose-stimulated pancreatic β-cells, B-Raf activity is increased, while Raf-1 activity is under the detection limit (Duan and Cobb, 2010). Thus, B-Raf is the primary protein kinase involved in the rapid activation of ERK1/2 in glucose-treated pancreatic β-cells. Expression of a dominant-negativ
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How do increased levels of ammonia as observed in
2022-11-03
How do increased levels of ammonia as observed in clinical HE constrain synaptic plasticity? Numerous studies have investigated the modulation of signal transduction pathways activated in LTP or LTD irrespective of being necessary or sufficient for changes in synaptic efficacy (Wen et al., 2013). Ye
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A candidate protein for the regulation of
2022-11-03
A candidate protein for the regulation of AMPAR transport is CaMKII, a Ca2+-dependent kinase with diverse cellular functions. With respect to synaptic transmission, CaMKII is recognized as a key synaptic protein that is required to modify the number of synaptic AMPARs in response to LTP and LTD stim
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Recently rather than predicting categorical variables
2022-11-03
Recently, rather than predicting categorical variables as in classification, several studies begin to estimate continuous clinical variables from p2y receptor images. Therefore, instead of classify a subject into binary or multiple pre-determined categories or stages of the disease, regression focu
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Our in vitro data show that CyaA does not
2022-11-03
Our in vitro data show that CyaA does not play a critical role in the bacterial adherence to mammalian cells. This observation is in contrast to previous studies that reported a role for CyaA in FHA-mediated adherence of B. pertussis bacteria to the respiratory epithelial tetraethylammonium [37,38]
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Whereas more research is needed to
2022-11-03
Whereas more research is needed to identify the precise mechanism by which FIN exerts its antidyskinetic effect, the geldanamycin that it can negatively modulate dopaminergic transmission is also supported by our previous findings. Indeed, we have previously shown that FIN completely reversed the b
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CYP A is one of the key metabolizing
2022-11-03
CYP3A4 is one of the key metabolizing GSK J4 receptor of the cytochrome P450 (CYP) superfamily of heme-containing monooxygenases. As the CYP family of enzymes plays important roles not only in the xenobiotic metabolism and detoxification of a large number of drugs, but also in the biosynthesis of e
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Aurora A and B are required for the control
2022-11-03
Aurora A and B are required for the control of mitosis whereas Aurora C is mainly invoved in meiosis (Goldenson and Crispino, 2015). Interestingly, Aurora B is partnered with inner centromere protein (INCENP), survivin and Borealin to form a chromosomal passenger complex (CPC) that is critical for t
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We have recently reported a regulatory effect of
2022-11-03
We have recently reported a regulatory effect of quercetin on the AChE activity in the brainstem during the demyelination and remyelination process [17]. It has also been observed that there is a protective effect on lipid peroxidation and worsening of motor functions caused by loss of myelin in the
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