• A role for YAP in mediating resistance

  2023-11-22

  

  A role for YAP in mediating resistance to EGFR inhibition has also been described [28], [29]. In line with these evidences, we observed increased YAP activation in all the generated EGFR TKI–resistant cells, testified by decreased phosphorylation on the inhibitory serine 127, enhanced nuclear locali

• We demonstrate a role for low oxygen

  2023-11-22

  

  We demonstrate a role for low oxygen to regulate ATX mRNA in hepatocyte-derived HuH7 chpg and human liver slices, consistent with reports of increased ATX expression in a variety of tumours that are frequently hypoxic. Importantly, we show a positive association between elevated ATX mRNA levels in

• Endoplasmic reticulum ER stress resulting

  2023-11-22

  

  Endoplasmic reticulum (ER) stress resulting from accumulation of misfolded proteins in ER lumen stimulates a chain of adaptive responses termed as the unfolded protein response (UPR). Glucose related protein (GRP78/BiP), key ER chaperone essential for the activation of the ER-transmembrane signaling

• br Materials and methods br Results

  2023-11-22

  

  Materials and methods Results and discussion In our previous studies (Matarneh et al., 2017), mitochondria were mechanically disrupted and separated into supernatant and pellet fractions by centrifugation. The causative agent for enhnced glycolytic flux was shown to be a protein that resides i

• Because of the formation of phosphoenzyme intermediates the

  2023-11-22

  

  Because of the formation of phosphoenzyme intermediates, the enzymatic perhexiline australia of P-ATPases can be divided into steps that include a kinase activity, by which an aspartate residue on the enzyme is phosphorylated, and a phosphatase activity, by which the phosphoenzyme is dephosphorylat

• The PDZ domains of DLG

  2023-11-22

  

  The PDZ domains of DLG interact with tumor suppressor proteins, APC and PTEN, as well as with several viral oncoproteins such as the E6 protein present in oncogenic human papillomavirus (reviewed in [177]). It has been reported that overexpression of DLG in fibroblasts impairs the events in the G0/G

• Aggregated A species have been studied by

  2023-11-22

  

  Aggregated Aβ species have been studied by an array of biophysical techniques, including atomic force microscopy (AFM) [55], transmission electron microscopy (TEM) [56], [57], X-ray diffraction [58], Fourier transform infrared (FTIR) [59], [60], circular dichroism (CD) [61], and nuclear magnetic res

• Rising depolarization was observed during and

  2023-11-21

  

  Rising depolarization was observed during and decaying depolarization after the photostimulation (Fig. 1D). The slow decrease of the firing rate after photostimulation is also a remarkable characteristic of the striatal neuron (Figs. 1E, 2 and 3), since the cortex pyramidal neurons (data not shown)

• Preclinical models indicate roles for adiponectin in the mai

  2023-11-21

  

  Preclinical models indicate roles for adiponectin in the maintenance of hepatic lipid metabolism. Adiponectin overexpression prevents accumulation of triglycerides or the deleterious lipid metabolites diacylglycerols or ceramides [5,8]. Direct manipulation of adiponectin expression demonstrates a po

• We aim to evaluate the

  2023-11-21

  

  We aim to evaluate the AK in regulating adenosine signaling in the retina. It was reported that the degree of zilpaterol injury directly depends on expression levels of AK and the resulting extracellular levels of adenosine (Boison, 2006). Indeed, transgenic mice overexpressing AK are highly suscep

• The structures of these compounds were confirmed

  2023-11-21

  

  The structures of these compounds were confirmed from their spectral and micro analytical data. Based on [M + H] 367, molecular formula of was established as CHON. The IR spectrum of showed guanylate cyclase due to CO stretching at 1700 Cm & OH stretching at 3188 Cm indicating that compound contain

• We have previously shown that the antinociceptive effect of

  2023-11-21

  

  We have previously shown that the antinociceptive effect of tramadol, an analgesic that, like paracetamol is able to increase serotonin levels within CNS, is potentiated or antagonized respectively by a 5-HT1A/B nonspecific Carfilzomib blockade or activation (Rojas-Corrales et al., 2000). Moreover,

• For the NSCLC patients with EGFR activating

  2023-11-21

  

  For the NSCLC patients with EGFR-activating mutations, EGFR-TKIs (gefitinib and erlotinib) are effective clinical therapies [21], [22]. However, approximately 10% of patients harboring EGFR-sensitizing mutations exhibit intrinsic resistance, and up to 40% do not attain a major response to treatment

• Stroke also known as a

  2023-11-21

  

  Stroke, also known as a cerebrovascular accident or ampicillin sodium attack, is one of the leading causes of death and disability worldwide (Haley et al., 2017; Hankey, 2017; Lie et al., 2017). According to the data released by the World Health Organization (WHO), stroke occurs every 5 s worldwide

• br Materials and Methods br Results br Discussion HETE is

  2023-11-21

  

  Materials and Methods Results Discussion 15-HETE is a predominant eicosanoid in pulmonary vascular remodeling, and it could promote hypoxia-induced PAH via its involvement in the regulation of proliferation and cell cycle progression in PASMCs. To understand its role in HPH, we have previou

15304 records 234/1021 page Previous Next First page 上5页 231232233234235 下5页 Last page